Methadone is a synthetic, long-acting opioid with pharmacologic actions qualitatively similar to morphine and is active by oral and parenteral routes of administration. It is primarily a μ-receptor agonist and may mimic endogenous opioids, enkephalins, and endorphins and affect the release of other neurotransmitters acetylcholine, norepinephrine, substance P, and dopamine.
This accounts for its analgesic and antitussive properties, respiratory depression, sedation, decrease in bowel motility, increase in biliary tone, hormone regulation and increase of prolactin and growth hormone release, miotic pupils, nausea, and hypotension. Patients develop tolerance and physical dependence following repeated use.
The tolerance may be only partial for most of the pharmacologic effects. An abstinence syndrome consisting of lacrimation, rhinorrhea, sneezing, gooseflesh, nausea, vomiting, fever, chills, tremor, and tachycardia occurs on abrupt discontinuation of the opiate or the administration of an antagonist such as naloxone hydrochloride. Buy methadone online
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Buy methadone online, There is cross-tolerance and cross-dependence among the various opiates. This is the premise for using methadone in the detoxification and maintenance of heroin people addicted to heroin. Due to the long half-life and duration of action of methadone, the abstinence syndrome is delayed and prolonged but less severe than that from a shorter-acting opiate such as heroin.
Methadone is a good therapeutic alternative to morphine sulfate and other opiate analgesics in the treatment of severe, chronic pain. It is well absorbed orally, has analgesic effects comparable to other μ-opiate receptor analgesics like morphine, has a long half-life, and is not metabolized to any active metabolites that may pose a risk to the patient.
Why Some People Attempt to Buy Methadone Online
As Healthline mentions, online pharmacies can help people who need convenience and have a prescription. There are safe and legal ways to buy medication online. There are a few ways to tell legitimate sellers apart from unauthorized sellers.
- Legitimate websites encourage you to follow the law and require you to upload a prescription. Unauthorized websites may be based outside the United States and actively encourage you to break the law.
- Marketing is not as common. Illegitimate websites send email blasts and offer specials where prices seem a bit too low.
- Many illegitimate websites look very professional, and they may even look better than websites for licensed pharmacies.
Methadone comes with strict regulations regarding its prescription and distribution. Initially, you have to visit a clinic daily to get your dose of methadone. You can’t take it at home.
Over time, you may earn the privilege to get take-home doses of the drug. This is after you have demonstrated a period of stability and compliance.
Risks of Buying Methadone Online
There are always risks to buying drugs online, even if methadone is legal when you have a prescription. Some of the risks of buying methadone online are:
Diluted product. Your methadone might be weak and will not be effective in treating your cravings.
Expired methadone. Products you buy online may be very cheap because they are expired. This means they cannot help you, and you are spending money on something that is not useful to you.
Improper storage. Some medication needs to be stored at a certain temperature, and you have no way of knowing whether or not it was stored the right way.