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Makatussin is an opioid pain medication. An opioid is sometimes called a narcotic. Makatussin is used to treat mild to moderately severe pain. Makatussin may also be used for purposes not listed in Makatussin guide
Makatussin Comp Syrup with Codeine 80 ml Drug Uses
Makatussin Comp. is used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson’s disease. Makatussin Comp. is also used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold. Makatussin Comp. may also be used for purposes other than those listed in this medication guide.
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As a sleep aid, Makatussin Comp. should be taken approximately 30 minutes before bedtime. Take each dose with a full glass of water. Makatussin Comp. can be taken with or without food. For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.
To ensure that you get a correct dose, measure the liquid forms of Makatussin Comp. with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Never take more of this medication than prescribed for you. The maximum amount of Makatussin Comp. that you should take in any 24-hour period is 300 mg.
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Do not take Makatussin Comp. if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These products may contain medicines similar to Makatussin Comp., which could lead to an antihistamine overdose.
Before taking this medication, tell your doctor if you are taking any of the following medicines: anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion); medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); or any other medications that make you feel drowsy, sleepy, or relaxed.
Codeine is contraindicated in patients who are known to be ultrafast CYP2D6 metabolisers: Codeine is converted in its active metabolite morphine by the hepatic isoenzymes CYP2D6, some of which exist with genetic polymorphisms.
Patients with an “ultrafast CYP2D6 metabolizer” phenotype have a high CYP2D6 activity, so toxic serum levels of morphine can occur even at low doses. These “ultrafast metabolizers” can show symptoms of overdose, such as dizziness, deep sedation, shortness of breath, nausea and vomiting, up to a respiratory and cardiac arrest.
In nursing mothers who are “ultrafast CYP2D6 metabolizers” and receive codeine therapy, the risk of overdose and death of the newborn due to a high morphine serum concentration is high. In the case of signs of opioid toxicity, close monitoring of patients is of enormous importance.
In combination with centrally damping pharmaceuticals or alcohol, a mutual effect may increase, including the risk of respiratory depression.
Concomitant administration of MAO inhibitors can lead to an increase in central nervous effects such as arousal, convulsions, hallucinations, sweating, changes in blood pressure and muscle stiffness. Makatussin comp.
Cough syrup should therefore not be used until two weeks after the end of therapy with MAO inhibitors. With simultaneous intake of analgesics (e.B. acetylsalicylic acid or paracetamol) the analgesic effect of these substances may mutually strengthen.
Drugs that affect liver metabolism can lead to increased blood levels of codeine. Do not give together with expectorants, since the more reproduced mucus cannot be coughed off because of the antitussive effect of dihydrocodeine.
[A NEW TECHNIC OF THE ELECTRO-ACOUSTIC RECORDING OF COUGH AND ITS USE IN THE EVALUATION OF THE EFFECT OF SOME ANTITUSSIVE AGENTS].Med Welt. 1964 Jun 13;24:1317-20. PMID: 14244228 German. No abstract available.
Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.Drugs Exp Clin Res. 2004;30(4):133-41. PMID: 15553659
TRPV1 antagonists as potential antitussive agents.Lung. 2008;186 Suppl 1:S59-65. doi: 10.1007/s00408-007-9032-z. Epub 2007 Oct 10. PMID: 17926096 Review.
Codeine: A Relook at the Old Antitussive.J Assoc Physicians India. 2015 Apr;63(4):80, 82-5. PMID: 26591180
Antitussive effect of nociceptin/orphanin FQ in experimental cough models.Pulm Pharmacol Ther. 2002;15(3):213-6. doi: 10.1006/pupt.2002.0357. PMID: 12099766 Review.